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| In the majority of cases, patients with moderate-to-severe OCD will be on an SSRI for 12 months or more. The doctor will review the patient periodically to determine whether medication therapy should continue. Side effects associated with SSRI usage include headaches, nausea and vomiting. However, nearly all patients who continue taking the medication feel better within a couple of weeks.
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There is a very small risk of heightened anxiety, suicidal thoughts, and thoughts of self-harm. If you experience any side effects from any medication, tell your doctor immediately. Coming off SSRIs must be done gradually and under a doctor's supervision. Anafranil (Clomipramine) - is a TCA (tricyclic antidepressant) that is FDA-approved for the treatment of OCD. Clomipramine is less commonly recommended for OCD treatment because it is associated with more side effects. Doctors tend to prescribe it when patients cannot tolerate SSRIs.
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